Fungal Burden and Raised Intracranial Pressure Are Independently Associated With Visual Loss in Human Immunodeficiency Virus-Associated Cryptococcal Meningitis

Abstract Among 472 patients with human immunodeficiency virus-associated cryptococcal meningitis, 16% had severe visual loss at presentation, and 46% of these were 4-week survivors remained severely impaired. Baseline cerebrospinal fluid opening pressure ?40 cmH2O (adjusted odds ratio [aOR], 2.56; 95% confidence interval [CI], 1.36–4.83; P = .02) fungal burden >6.0 log10 colonies/mL (aOR, 3.01; CI, 1.58–5.7; .003) independently associated loss.